Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Changes in the expressions of E-selectin, adiponectin and serum ferritin in patients with diabetic retinopathy, and their correlations

Zhou Li¹ , Zhou Zheng², Wei Xiaodan², Tian Bin³, Ji Yuanhong³

¹Ophthalmology Department, Tangshan City Workers Hospital Group Rehabilitation Hospital; ²Ophthalmology Department, Tangshan City Workers Hospital; ³The Department of Rehabilitation, Tangshan City Workers Hospital Group Rehabilitation Hospital, Tangshan, Hebei 063000, China.

For correspondence:- Zhou Li Email: vb1336@163.com

Accepted: 28 June 2018 Published: 28 July 2018

Citation: Li Z, Zheng Z, Xiaodan W, Bin T, Yuanhong J. Changes in the expressions of E-selectin, adiponectin and serum ferritin in patients with diabetic retinopathy, and their correlations. Trop J Pharm Res 2018; 17(7):1433-1437 doi: 10.4314/tjpr.v17i7.29

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study changes in the expressions of E-selectin, adiponectin (APN) and serum ferritin in patients with diabetes retinopathy (DN) and their correlations with DN.

Methods: Diabetes patients (180) in Tangshan City Workers Hospital Group Rehabilitation Hospital from February 2014 to February 2015 were recruited and divided into three groups: 56 non-diabetic retinopathy (NDR) cases, 60 non-proliferative diabetic retinopathy (NPDR) cases and 64 proliferative diabetic retinopathy (PDR) cases. Serum levels of E-selectin, adiponectin (APN), ferritin (SF), fasting plasma glucose (FPG) and fasting insulin (FINS) were separately assayed, and their correlations analyzed.

Results: There were no significant differences between patients in the three groups with respect to sex, age, blood pressure and blood lipids (p > 0.05). Serum E-selectin, APN and SF levels gradually and significantly increased in the order: NDR group F6; NPDR group F6; PDR group (p < 0.05).

Conclusion: E-selectin, APN and SF levels of patients with DN increase with aggravation of the disease. The decrease in E-selectin, APN and SF levels may have a positive effect on the improvement of the status of DN patients.

Keywords: Diabetic retinopathy, E-selectin, Adiponectin, Serum ferritin